Psychometric properties of the EORTC QLQ-C30 in Uganda

Abstract Background Self-reported measures play a crucial role in research, clinical practice and health assessment. Instruments used to assess self-reported health-related quality of life (HRQoL) need validation ensure that they measure what are intended to, detect true changes over time differentiate between subjects. A generic instrument measuring HRQoL adapted for use among people living with cancer Uganda is lacking; therefore, this study aimed evaluate the psychometric properties European Organisation Research Treatment Cancer (EORTC) QLQ-C30 patients Uganda. Methods Adult various types (n = 385) cared at Institute answered EORTC Luganda or English language, two most spoken languages country. The language versions were evaluated regard data (floor ceiling effects missing responses), reliability (internal consistency) validity (construct, known-group criterion). Construct was examined through confirmatory factor analysis (CFA). Mean scores compared groups differing disease stage validity. Criterion according associations subscales (Global Physical function) Karnofsky Performance Scale (KPS). Results Floor observed several scales versions. All exception Cognitive function (Luganda α 0.66, 0.50) had acceptable Cronbach’s alpha values (0.79–0.96). CFA yielded good fit indices both (RMSEA 0.08, SRMR 0.05 CFI 0.93). Known-group demonstrated statistically significant better reported by stages I–II those III–IV. supported positive correlations KPS r 0.75, 0.76) Global 0.59, 0.72). Conclusion appear be valid reliable can recommended research adult Ugandans cancer. However, cognitive scale did not reach internal consistency needs further evaluation.