PSXV-3 Genome-Wide Association Study for Sweat Gland Area in Multi-Breed Brahman-Angus Population

Abstract Thermal stress in subtropical regions is a major limiting factor beef cattle productions with around $370 million being lost annually due to reduced performance. About 45% of the United States are southern and southeastern states where tropical climates most prevalent. Cattle utilize sweating dispense their excess heat allowing them return thermoneutral zone. The objective this study was conduct genome-wide association on sweat gland area Multi-breed Angus-Brahman herd University Florida. Skin samples were collected along shoulder from 337 cows varying Brahman Angus percentages. Cows genotyped Bovine GGP F250k array. biopsies processed into histology slides then ImageJ software used measure area. A general linear model test significance breed composition age group Breed had significant effect (P < 0.0001 P 0.0001, respectively), increasing percentage. Quality control conducted using BLUPF90 including call rate 0.90 minor allele frequency 0.01 which left 125,035 SNPs available for single-step genome wide analysis. fit single locus mixed each marker. There located MINDY1 PRUNE1 gene, involved cell proliferation induction motility. These results show that selection these SNPs, can improve ability adapt thermal stress.