Psoriasis Bench to Bedside

From bench to bedside

Because the microcirculation has emerged as an important reanimation target, appropriate methods to monitor the microcirculatory function are crucial. Several teams have now succeeded in crossing this bridge from bench to bedside, but the choice of the tissues of interest remains a debate. The potential accessible vascular beds that doctors could use in reanimation strategies and the relationsh...

Bench to bedside review

From Bench to Bedside

Since the initial experiments nearly a decade ago, remarkable progress has been made in the field of vascular gene transfer, and trials with human subjects already are under way. The potential of vascular wall gene transfer as therapy for various vascular diseases is considerable.1,2 The purpose of this review is 2-fold: (1) to delineate the methods and principles underlying vascular gene trans...

Asthma: bench to bedside

P108 Table Variable Asthmatic (n = 34) Mean (95% CI) Inflammatory (n = 20) Mean (95% CI) Non-inflammatory (n = 18) Mean (95% CI) Overall ANOVA Age (years) 49.9 (43.6 to 56.1) 54.1 (45.9 to 62.2) 50.2 (45.7 to 54.6) 0.577 Duration rhinitis (years) 15.9 (11.5 to 20.4) 14.3 (6.3 to 22.3) 17.7 (10.3 to 25.0) 0.773 Exhaled NO (ppb)* 34.3 (25.9 to 45.3) 48.2 (36.0 to 64.5) 15.4 (11.1 to 21.3) ,0.005 ...

Translational Antidote Research: A Bedside to Bench Tale

Although antidote development should proceed in an orderly fashion from observation, to experimental and safety studies, to clinical trials, this sequence is not always precisely followed. The development of fomepizole as an antidote for toxic alcohol and glycol poisoning is an example of how this may not be the case. Interest in the development of fomepizole was spurred in the 1960s. Shortly t...