Psoriasis, An inflammatory condition associated with oxidative stress

Background: Psoriasis is a chronic inflammatory skin disease characterized by pathological lesions due to various exogenous and endogenous factors. Oxidative stress can be one of the causes for occurrence psoriasis as well significant contributor its progression. Skin exposure number irritants or proinflammatory agents including UVA UVB generates ROS through oxidative burst in infiltrating leukocytes at site inflammation which damages cells. Measurement marker like lipid peroxidation product Malondialdehyde (MDA) Nitric Oxide end products (NO2+NO3) along with hs-CRP patients uncover their role causation, progression development co-morbidities timely prevention significantly improve quality life patients.
 Aims Objectives: To measure Materials Methods: Fifty mainly plaque type either sex, age group 35 ± 15.5 (range: 7-79) years were taken following inclusion exclusion criteria. evaluate malondialdehyde (NO2 + NO3) measured. was measured an correlation severity duration evaluated.
 Results: A increase (MDA), (NOx) levels (P<0.001) noted Psoriatic compared controls. There positive between MDA, NOx disease. The MDA also showed trend.
 Conclusion: factors lead causation contribute co-morbidities. By measuring early process we employ preventive strategies better management survival life.