PSA nadir and risk of non-organ-confined disease in radical prostatectomy preceded by neoadjuvant androgen deprivation
نویسندگان
چکیده
منابع مشابه
Role of Androgen Deprivation in Patients Undergoing Radical Prostatectomy
Radical prostatectomy (RP) as a monotherapy is most likely to be curative only in patients with truly organ-confined PC. Several clinical and pathologic factors affect recurrence following RP. In an effort to improve the outcome Androgen deprivation therapy (ADT) has been evaluated in conjunction with RP. In this review we summarize the available evidence from prospective randomized studies con...
متن کاملNeoadjuvant hormonal deprivation for patients undergoing radical prostatectomy.
The purpose of this study is to evaluate the therapeutic effect of radical prostatectomy combined with preoperative neoadjuvant hormonal ablation therapy for prostate cancer (PCa). In this study, a total of 31 patients with local PCa underwent radical prostatectomy; of these, 12 patients underwent preoperative hormonal deprivation with a combination of goserelin and flutamide for a period of 5....
متن کاملEfficacy of androgen deprivation therapy for localized prostate cancer: analysis of pT0 evaluated by radical prostatectomy specimen.
AIM In order to investigate which types of localized prostate cancer can be treated most effectively by androgen deprivation therapy (ADT), cases of no residual cancer in radical prostatectomy specimens (pT0) after neoadjuvant ADT were analyzed. PATIENTS AND METHODS Patients with localized prostate cancer who underwent radical prostatectomy after neoadjuvant ADT were investigated retrospectiv...
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More than 1,112,000 patients worldwide were estimated to be diagnosed with prostate cancer (PC) in 2012, resulting in more than 307,000 deaths (Ferlay et al., 2013). In Japan, PC is the fourth, most commonly diagnosed cancer in men, with an estimated incidence of 51,534 cases (11.8% among 437,787 cancer patients of all primary sites) in 2008, and accounts for about 9,800 deaths annually in the ...
متن کاملEffect of neoadjuvant androgen deprivation on circulating prostate cells in the bone marrow of men undergoing radical prostatectomy.
Our objective was to determine the effect of neoadjuvant hormonal therapy on the presence of circulating prostate cells in patients undergoing radical prostatectomy for prostate cancer. A total of 60 patients at high risk for extraprostatic disease were analyzed for the presence of circulating prostate cells using reverse transcriptase PCR (RTPCR) amplification of the prostate-specific antigen ...
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ژورنال
عنوان ژورنال: Prostate Cancer and Prostatic Diseases
سال: 1999
ISSN: 1365-7852,1476-5608
DOI: 10.1038/sj.pcan.4500342