Provisional in-silico biopharmaceutics classification (BCS) to guide oral drug product development
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چکیده
منابع مشابه
Provisional in-silico biopharmaceutics classification (BCS) to guide oral drug product development
The main objective of this work was to investigate in-silico predictions of physicochemical properties, in order to guide oral drug development by provisional biopharmaceutics classification system (BCS). Four in-silico methods were used to estimate LogP: group contribution (CLogP) using two different software programs, atom contribution (ALogP), and element contribution (KLogP). The correlatio...
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The biopharmaceutical classification system (BCS) is now well established and utilized for the development and biowaivers of immediate oral dosage forms. The prediction of BCS class can be carried out using multilabel classification. Unlike single label classification, multilabel classification methods predict more than one class label at the same time. This paper compares two multilabel method...
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The Biopharmaceutics Classification System (BCS) was developed for prediction of in vivo pharmacokinetic performance of drug products from measurements of permeability and solubility. If the permeability criteria changed with metabolism criteria than it may be useful in predicting overall drug disposition, including routes of drug elimination and the effects of efflux and absorptive transporter...
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Submit Manuscript | http://medcraveonline.com Abbreviations: ADME: Absorption, Distribution, Metabolism and Excretion; NDA: New Drug Application; FDA: Food and Drug Administration; CYP: Cytochrome P; UGT: Uridine DiphosphoGlucuronosyl Transferase; NAT: N-Acetyl Transferase; GST: Glutathione S-Transferase; ST: Sulfo Transferase; QSAR: Quantitative Structure–Activity Relationships; PCA: Principal...
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The objective was to assess the impact of larger than conventional amounts of 14 commonly used excipients on Biopharmaceutics Classification System (BCS) class 3 drug absorption in humans. Cimetidine and acyclovir were used as model class 3 drugs across three separate four-way crossover bioequivalence (BE) studies (n = 24 each) in healthy human volunteers, denoted as study 1A, 1B, and 2. In stu...
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ژورنال
عنوان ژورنال: Drug Design, Development and Therapy
سال: 2014
ISSN: 1177-8881
DOI: 10.2147/dddt.s68909