Proton pump inhibitors as treatment of laryngeal disorders among patients with gastroesophageal reflux disease: a single-arm (pre and post) quasi-experimental study

Abstract Background Laryngopharyngeal reflux is a silent cause of laryngeal disorders which was documented in the last decade by many studies. This study aimed to evaluate prevalence GERD cases and effect treatment on these disorders. Methodology In this single-arm (pre post) quasi-experimental study, eighty patients with were examined for rigid laryngoscopy assessed Reflux Finding Score (RFS). Complaints evaluated using 9-item Symptom Index (RSI) questionnaire. Patients received medical form proton pump inhibitors (PPIs) only, they reassessed after 3 months improvement their symptoms signs RSI RFS systems compare patient complaints findings endoscopy pre- post-treatment. Results Among 80 confirmed cases, 70 (87.5%) suffered from Throat clearing postnasal drip most prevalent symptoms, ventricular obliteration erythema, vocal fold diffuse edema, posterior commissure hypertrophy detected signs. Significant both PPI therapy clearly observed. The resistance rate among our studied reported be 22.4%. Conclusion can considered as an inducer or disorders, significant direct proportional relationship between severity RFS. greatly improves high response (77.6%).