Prothymosin Alpha Selectively Enhances Estrogen Receptor Transcriptional Activity by Interacting with a Repressor of Estrogen Receptor Activity
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چکیده
منابع مشابه
Prothymosin alpha selectively enhances estrogen receptor transcriptional activity by interacting with a repressor of estrogen receptor activity.
We find that prothymosin alpha (PTalpha) selectively enhances transcriptional activation by the estrogen receptor (ER) but not transcriptional activity of other nuclear hormone receptors. This selectivity for ER is explained by PTalpha interaction not with ER, but with a 37-kDa protein denoted REA, for repressor of estrogen receptor activity, a protein that we have previously shown binds to ER,...
متن کاملHistone H1 represses estrogen receptor alpha transcriptional activity by selectively inhibiting receptor-mediated transcription initiation.
Chromatin is the physiological template for many nuclear processes in eukaryotes, including transcription by RNA polymerase II. In vivo, chromatin is assembled from genomic DNA, core histones, linker histones such as histone H1, and nonhistone chromatin-associated proteins. Histone H1 is thought to act as a general repressor of transcription by promoting the compaction of chromatin into higher-...
متن کاملHistone H1 Represses Estrogen Receptor Transcriptional Activity by Selectively Inhibiting Receptor-Mediated Transcription Initiation
Chromatin is the physiological template for many nuclear processes in eukaryotes, including transcription by RNA polymerase II. In vivo, chromatin is assembled from genomic DNA, core histones, linker histones such as histone H1, and nonhistone chromatin-associated proteins. Histone H1 is thought to act as a general repressor of transcription by promoting the compaction of chromatin into higher-...
متن کاملTranscriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases.
Histone acetyltransferases and deacetylases are recruited by transcription factors and adapter proteins to regulate specific subsets of target genes. We were interested in identifying interaction partners of histone deacetylase 1 (HDAC1) that might be involved in conferring target or substrate specificity. Using the yeast two-hybrid system, we isolated the repressor of estrogen receptor activit...
متن کاملEstrogen Receptor Activity
Natural estrogens modulate the activity of target cells by binding at least two intranuclear receptors. ERα and ERβ belong to a large family of structurally related transcription factors that are well conserved from the evolutionary and functional points of view. The considerable progress made recently in comprehending ER structure (figs. 6–1 and 6–2) and mechanism of action (fig. 6–2) provides...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2000
ISSN: 1098-5549,0270-7306
DOI: 10.1128/.20.17.6224-6232.2000