Proteomics and autoimmune kidney disease

Autoimmune Kidney Disease: Distinct Roles

Obesity and Kidney Disease

The rise in the prevalence of chronic kidney disease (CKD) and an increase in the prevalence of obesity in parallel in the recent years is a great concern. CKD increases the rate of cardiovascular disease (CVD) and development of end-stage renal disease, and leads to premature death. Although no direct causality link between obesity and CKD can yet be established, this appears highly probable. ...

Proteomics technologies for the study of autoimmune disease.

Autoimmune disease affects 3% of the US population, and likely a similar percentage of the population of the industrialized world (1). Although remarkable progress toward understanding immune function has been made over the last 4 decades in terms of the role of the major histocompatibility complex and the nature of lymphocyte antigen receptors that confer specificity to autoimmune responses, u...

Genomics and proteomics: Applications in autoimmune diseases

Tremendous progress has been made over the past decade in the development and refinement of genomic and proteomic technologies for the identification of novel drug targets and molecular signatures associated with clinically important disease states, disease subsets, or differential responses to therapies. The rapid progress in high-throughput technologies has been preceded and paralleled by the...

Mass spectrometry based proteomics in the diagnosis of kidney disease.

PURPOSE OF REVIEW Laser microdissection (LMD) and mass spectrometry (MS) is a new technique that consists of dissection of glomeruli, tryptic digestion of dissected material, analysis by MS and generation of a protein profile using different algorithms. The review focuses on the use of this methodology as an ancillary technique in a clinical laboratory for the diagnosis of kidney diseases. RE...