Proteomic screening identifies a YAP-driven signaling network linked to tumor cell proliferation in human schwannomas
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چکیده
منابع مشابه
Proteomic screening identifies a YAP-driven signaling network linked to tumor cell proliferation in human schwannomas.
BACKGROUND Inactivation of the NF2 gene predisposes to neurofibromatosis type II and the development of schwannomas. In vitro studies have shown that loss of NF2 leads to the induction of mitogenic signaling mediated by receptor tyrosine kinases (RTKs), MAP kinase, AKT, or Hippo pathways. The goal of our study was to evaluate the expression and activity of these signaling pathways in human schw...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2014
ISSN: 1523-5866,1522-8517
DOI: 10.1093/neuonc/nou020