Proteomic Approach for Biomarker Discovery in Radioadaptive Responses-Age-Dependent Variations of Cell Response to Low-Dose Radiation-

Proteomic Approaches to Biomarker Discovery in Cutaneous T-Cell Lymphoma

Cutaneous T-cell lymphoma (CTCL) is the most frequently encountered type of skin lymphoma in humans. CTCL encompasses multiple variants, but the most common types are mycosis fungoides (MF) and Sezary syndrome (SS). While most cases of MF run a mild course over a period of many years, other subtypes of CTCL are very aggressive. The rapidly expanding fields of proteomics and genomics have not on...

Activation of Radioadaptive Response via Injected Serum of Irradiated Rats with Low Doses of Ionizing Radiation

Introduction: One of the protective concepts in the interpretation of radiation damage in radiobiology is the radioadaptive response. The objective of this present report is to evaluate the induction of radioadaptive response in male rats by injection of pre-irradiated serum with low doses X-radiation intraperitoneally.   Materials and Methods: 80 male adul...

Proteomic methods for biomarker discovery in urine.

Many challenges exist with disease-state biomarker identification. These challenges include sample heterogeneity, poorly designed sample sets, insufficient numbers of samples, as well as inconvenient workflows, inadequate methodology, and development of false-positive markers resulting from protein degradation during sample handling. Yet despite these difficulties, substantial progress has been...

METABONOMICS APPROACH TO BIOMARKER DISCOVERY Volume VI: Dose and Time Response of Liver Toxicant

Innovative proteomic approaches for cancer biomarker discovery.

Substantial technological advances in proteomics and related computational science have been made in the past few years. These advances overcome in part the complexity and heterogeneity of the human proteome, permitting quantitative analysis and identification of protein changes associated with tumor development. Here, we discuss some of these advances that are uncovering new cancer biomarkers ...