Proteome Serological Determination of Tumor-Associated Antigens in Melanoma
نویسندگان
چکیده
منابع مشابه
Proteome Serological Determination of Tumor-Associated Antigens in Melanoma
Proteome serology may complement expression library-based approaches as strategy utilizing the patients' immune responses for the identification pathogenesis factors and potential targets for therapy and markers for diagnosis. Melanoma is a relatively immunogenic tumor and antigens recognized by melanoma-specific T cells have been extensively studied. The specificities of antibody responses to ...
متن کاملIdentification of melanoma antigens using a Serological Proteome Approach (SERPA).
BACKGROUND Melanoma is an intractable cancer with a poor prognosis and increasing prevalence worldwide. Specific biomarkers for early diagnosis have yet to be found. MATERIALS AND METHODS Serum samples from melanoma patients and healthy volunteers were utilized for identifying melanoma marker proteins using a serological proteome approach. Specifically, G361 cell protein spots separated by 2-...
متن کاملTumor-associated antigens in human malignant melanoma.
Several studies have now clearly indicated the presence of tumor-associated and tumor-specific antigens in cells of human malignant melanoma. These antigens have been identified by means of several quite different techniques, including the use of antibodies detectable against the antigens, either by means of immunofluorescence, (1-5) cytotoxicity (4, 6, 7) or by extracting the antigen and obtai...
متن کاملHuman monoclonal antibodies directed against melanoma tumor-associated antigens.
To analyze the humoral immune response to melanoma, human-mouse hybridomas were generated by the fusions of regional lymph node lymphocytes of patients with the mouse myeloma cell line M5. Six stable hybridomas were cloned from six separate lymphocyte parents obtained from three patients. Ascites were obtained from nude mice after i.p. injection with cultured hybridoma cells. The monoclonal ant...
متن کاملEffect of Immune Responses Against Hydatid Cyst Antigens on Growth of Melanoma Tumor
Background: Hydatid cyst is the larval stage of the tape worm parasite, Echinococcus granulosus. Human is infected by ingestion of parasite ova excreted in dog feces. The anticancer activity of different antigens of hydatid cyst has been reported in the previous works. In this research, the role of immune system in induction of this anticancer activity has been investigated.Materials and Method...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2009
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0005199