منابع مشابه
Perineuronal nets in neurodegeneration
At the end of the 19 th century, Camillo Golgi discovered that neurons were enwrapped by a net, but it was only recently that neuroscientists started to intensely investigate the role of this mysterious reticular structure. Today, perineuronal nets (PNNs) are known to be lattice-like extracellular matrix aggregates surrounding synapses at the soma, proximal axons and dendrites of several types ...
متن کاملDiverse functions of perineuronal nets.
Perineuronal nets represent well-organised components of the extracellular matrix, which are surrounding cell bodies, dendrites, and axon segments of a particular class of neurones as well as forming lattice-like structures. The role of perineuronal nets is not fully elucidated yet. Perineuronal nets may play a beneficial role by stabilizing the extracellular milieu assuring the characteristic ...
متن کاملPerineuronal Nets and CNS Plasticity and Repair
1Department of Neuroscience, Neuroscience Institute of Turin (NIT), University of Turin, 10100 Turin, Italy 2Neuroscience Institute of the Cavalieri-Ottolenghi Foundation (NICO), Regione Gonzole 10, Orbassano, 10043 Turin, Italy 3Netherlands Institute for Neuroscience (NIN), 1105 BA Amsterdam, Netherlands 4John van Geest Centre for Brain Repair, Department of Clinical Neuroscience, University o...
متن کاملSpatial patterns and cell surface clusters in perineuronal nets.
Perineuronal nets (PNN) ensheath GABAergic and glutamatergic synapses on neuronal cell surface in the central nervous system (CNS), have neuroprotective effect in animal models of Alzheimer disease and regulate synaptic plasticity during development and regeneration. Crucial insights were obtained recently concerning molecular composition and physiological importance of PNN but the microstructu...
متن کاملCaught in the Net: Perineuronal Nets and Addiction
Exposure to drugs of abuse induces plasticity in the brain and creates persistent drug-related memories. These changes in plasticity and persistent drug memories are believed to produce aberrant motivation and reinforcement contributing to addiction. Most studies have explored the effect drugs of abuse have on pre- and postsynaptic cells and astrocytes; however, more recently, attention has shi...
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ژورنال
عنوان ژورنال: ACTA HISTOCHEMICA ET CYTOCHEMICA
سال: 1999
ISSN: 0044-5991,1347-5800
DOI: 10.1267/ahc.32.141