منابع مشابه
Structure determination and thermodynamic stabilization of a selected engineered protein-protein complex
The interaction between two 6 kDa proteins has been investigated. The studied complex of micromolar affinity (Kd) consists of the Z domain derived from staphylococcal protein A and the related protein ZSPA1, belonging to a group of binding proteins denoted affibody molecules generated via combinatorial engineering of the Z domain. Affibody-target protein complexes are good model systems for str...
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The first release of Protein-protein Interactions Thermodynamic Database (PINT) contains >1500 data of several thermodynamic parameters along with sequence and structural information, experimental conditions and literature information. Each entry contains numerical data for the free energy change, dissociation constant, association constant, enthalpy change, heat capacity change and so on of th...
متن کاملThermodynamic prediction of protein neutrality.
We present a simple theory that uses thermodynamic parameters to predict the probability that a protein retains the wild-type structure after one or more random amino acid substitutions. Our theory predicts that for large numbers of substitutions the probability that a protein retains its structure will decline exponentially with the number of substitutions, with the severity of this decline de...
متن کاملThermodynamic Capacity of a Protein
We show that a protein can be trained to recognise multiple conformations, analogous to an associative memory, and provide capacity calculations based on energy fluctuations and information theory. Unlike the linear capacity of a Hopfield network, the number of conformations which can be remembered by a protein sequence depends on the size of the amino acid alphabet as lnA, independent of prote...
متن کاملThERMODYNAMIC THEORY OF STABILITY, STRUCTURE AND FLUCTUATIONS
The development of the thermodynamics of irreversible processes is outlined with a review of recent work and a discussion of the application of these concepts to physicochemical, biological and hydrodynamic phenomena. The extension of local thermodynamics to include a theory of stability and of fluctuations receives attention. The author concludes with remarks on the stability properties of che...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 2009
ISSN: 1521-6543,1521-6551
DOI: 10.1002/iub.214