Protein structure database search and evolutionary classification

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Protein structure database search and evolutionary classification

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Towards Scaleable Protein Structure Comparison and Database Search

Comparing protein structures in three dimensions is a computationally expensive process that makes a full scan of a protein against a library of known protein structures impractical. To reduce the cost, we can use an approximation of the three dimensional structure that allows protein comparison to be performed quickly to filter away dissimilar proteins. In this paper, we present a new algorith...

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The validation, enrichment and organization of the data stored in PDB files is essential for those data to be used accurately and efficiently for modelling, experimental design and the determination of molecular interactions. The Iditis protein structure database has been designed to allow the widest possible range of queries to be performed across all available protein structures. The Iditis d...

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Evolutionary Protein Structure Comparison

Comparing homologous objects are central to biology and the last decade have been dominated by this in the field of comparative genomics. However, many other objects than sequences in biology are homologous and can be subject to evolutionary study. Examples could be networks and structures. Protein structures have been compared for decades in a non-statistical and non-evolutionary way. There ar...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2006

ISSN: 0305-1048,1362-4962

DOI: 10.1093/nar/gkl395