Protein structural and mechanistic basis of progeroid laminopathies
نویسندگان
چکیده
منابع مشابه
Embryonic Senescence and Laminopathies in a Progeroid Zebrafish Model
BACKGROUND Mutations that disrupt the conversion of prelamin A to mature lamin A cause the rare genetic disorder Hutchinson-Gilford progeria syndrome and a group of laminopathies. Our understanding of how A-type lamins function in vivo during early vertebrate development through aging remains limited, and would benefit from a suitable experimental model. The zebrafish has proven to be a tractab...
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ژورنال
عنوان ژورنال: The FEBS Journal
سال: 2020
ISSN: 1742-464X,1742-4658
DOI: 10.1111/febs.15526