Protein Misfolding and Neurodegenerative Diseases
نویسندگان
چکیده
منابع مشابه
Protein Misfolding and Neurodegenerative Diseases
This special issue includes fifteen reviews and two original research articles by leading scientists in the fields of neu-ropathology, biochemistry, and cell biology, dealing with the role of protein aggregation and prion-like propagation of protein misfolding in neurodegenerative diseases. In the review article " Breaking the code of amyloid-í µí»½ oli-gomers, " available at the following link...
متن کاملProtein Folding and Misfolding: Neurodegenerative Diseases
Intrinsically disordered proteins or regions of proteins lack a well-defined structure, yet they carry out important functions often associated with the regulation of cell cycle and transcription. Due to these central roles in key cellular processes, their mutations are frequently involved in neurodegenerative diseases. These diseases are usually caused by the structural transition of disordere...
متن کامل-Synuclein Misfolding and Neurodegenerative Diseases
-Synuclein is an abundant presynaptic brain protein, misfolding, aggregation and fibrillation of which are implicated as critical factors in several neurodegenerative diseases. The list of the well-known synucleinopathies includes such devastating disorders as Parkinson’s disease, Lewy body variant of Alzheimer’s disease, diffuse Lewy body disease, dementia with Lewy bodies, multiple system atr...
متن کاملProtein Misfolding and Axonal Protection in Neurodegenerative Diseases
Genetically engineered mouse model studies show that neuronal dysfunction caused by protein aggregation/misfolding are reversible, indicating that injured neurons are alive even under disease states. Protein misfolding/aggregation in axons and distal dominant axonal degeneration are observed in a subgroup of degenerative diseases and in certain experimental conditions. Moreover, therapeutic app...
متن کاملDisulfide Bonding in Neurodegenerative Misfolding Diseases
In recent years an increasing number of neurodegenerative diseases has been linked to the misfolding of a specific protein and its subsequent accumulation into aggregated species, often toxic to the cell. Of all the factors that affect the behavior of these proteins, disulfide bonds are likely to be important, being very conserved in protein sequences and being the enzymes devoted to their form...
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ژورنال
عنوان ژورنال: International Journal of Cell Biology
سال: 2014
ISSN: 1687-8876,1687-8884
DOI: 10.1155/2014/217371