Protein liposomes-mediated targeted acetylcholinesterase gene delivery for effective liver cancer therapy

Abstract Background Effective methods to deliver therapeutic genes solid tumors and improve their bioavailability are the main challenges of current medical research on gene therapy. The development efficient non-viral vector with tumor-targeting has very important application value in field cancer Proteolipid integrated potential functional protein excellent delivery performance shown for targeted Results Herein, we prepared transferrin-modified liposomes (Tf-PL) acetylcholinesterase (AChE) liver cancer. We found that derived Tf-PL/AChE exhibited much higher transfection efficiency than commercial product Lipo 2000 premium targeting efficacy SMMC-7721 cells vitro . In vivo , could effectively target cancer, significantly inhibit growth xenografts grafted nude mice by subcutaneous administration. Conclusions This study proposed a proteolipid-mediated strategy treatment, which promising precise personalized