Protein folding for realists: A timeless phenomenon
نویسندگان
چکیده
منابع مشابه
Protein folding for realists: a timeless phenomenon.
Future research on protein folding must confront two serious dilemmas. (1) It may never be possible to observe at high resolution the very important structures that form in the first few milliseconds of the refolding reaction. (2) The energy functions used to predict structure from sequence will always be approximations of the true energy function. One strategy to resolve both dilemmas is to vi...
متن کاملFolding pathway of a lattice model for protein folding
The folding of a protein-like heteropolymer is studied by direct simulation of a lattice model that folds rapidly to a well-defined “native” structure. The details of each molecular folding event depend on the random initial conformation as well as the random thermal fluctuations of the polymer. By analysing the statistical properties of hundreds of folding events, a classical folding “pathway”...
متن کاملProtein Stability, Folding, Disaggregation and Etiology of Conformational Malfunctions
Estimation of protein stability is important for many reasons: first providing an understanding of the basic thermodynamics of the process of folding, protein engineering, and protein stability plays important role in biotechnology especially in food and protein drug design. Today, proteins are used in many branches, including industrial processes, pharmaceutical industry, and medical fields. A...
متن کاملA Potential Function for Protein Folding
One of the most difficult problems in computational chemistry is the prediction of the three-dimensional structure of a protein molecule given only its amino acid sequence. Although there are several programs for calculating the empirical or quantum mechanical energies, and there are more programs for either minimizing the energy as a function of conformation or for simulating the dynamics of a...
متن کاملA speed limit for protein folding.
Recent observations of fast steps in protein folding (1-3) address the following question: what is the shortest time that would be required for folding? The paper by Hagen et al. (4) in this issue of the Proceedings provides strong experimental support for a speed limit that is governed by diffusion. Diffusion is known to limit the rates of many of the activities of proteins, including enzymati...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Protein Science
سال: 1996
ISSN: 0961-8368
DOI: 10.1002/pro.5560050602