Protein delivery based on uncoated and chitosan-coated mesoporous silicon microparticles
نویسندگان
چکیده
منابع مشابه
Protein delivery based on uncoated and chitosan-coated mesoporous silicon microparticles.
Mesoporous silicon is a biocompatible, biodegradable material that is receiving increased attention for pharmaceutical applications due to its extensive specific surface. This feature enables to load a variety of drugs in mesoporous silicon devices by simple adsorption-based procedures. In this work, we have addressed the fabrication and characterization of two new mesoporous silicon devices pr...
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BACKGROUND Absorption of antigens onto chitosan microparticles via electrostatic interaction is a common and relatively mild process suitable for mucosal vaccine. In order to increase the stability of antigens and prevent an immediate desorption of antigens from chitosan carriers in gastrointestinal tract, coating onto BSA loaded chitosan microparticles with sodium alginate was performed by lay...
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BACKGROUND The production of protein drugs has recently increased due to advances in biotechnology, but their clinical use is generally limited to parenteral administration due to low absorption in non-parenteral administration. Therefore, non-parenteral delivery systems allowing sufficient absorption draw much attention. METHODS Microparticles (MP) were prepared using chitosan-4-thio-butylam...
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In this paper we demonstrate the possibility of modifying porous silicon (PSi) particles with surface chemistry and recognition molecules (antibodies) such that these devices could potentially be used for single-cell identification or sensing. This is achieved by modifying PSi Rugate filters via hydrosilylation with surface chemistry that serves firstly, to protect the silicon surfaces from oxi...
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ژورنال
عنوان ژورنال: Colloids and Surfaces B: Biointerfaces
سال: 2011
ISSN: 0927-7765
DOI: 10.1016/j.colsurfb.2011.07.049