Protective role of Bacopa monnieri against Rotenone- induced Parkinson’s disease in PC 12 cell lines
نویسندگان
چکیده
منابع مشابه
Alterations of Cholinergic Neurotransmission in Rotenone Induced Parkinson’s Disease: Protective Role of Bacopa Monnieri
Parkinson’s disease (PD) is the second most common neurodegenerative disorder. Dopaminergic anti-parkinsonian medications, cause drug-induced development of disabling motor complications in majority of patients with PD. Bacopa monnieri (BM), an Indian herb extensively used in Ayurveda, was tested on cholinergic system in Rotenone (RT) induced rat model of PD. Cholinergic system is affected due ...
متن کاملEvaluation of Rotenone Induced Parkinson's Disease on Glutamate Metabolism and Protective Strategies of Bacopa Monnieri
Department of Zoology, Division of Molecular Biology, Sri Venkateswara University, Tirupati-517502. A.P. India. ABSTRACT: Bacopa monnieri (BM; Family: Scrophulariaceae), also referred as Brahmi has been used for centuries in Ayurvedic system of medicine as a brain tonic, memory enhancer, revitaliser of sensory organs, antianxiety, cardio-tonic, diuretic, antidepressant and anticonvulsant agent,...
متن کاملProtective Role of Bacopa Monnieri on Induced Parkinson’s Disease with Particular Reference to Catecholamine System
Objective: Parkinson’s disease (PD) is the second most neurodegenerative disorder. Bacopa monnieri (BM), an Indian herb extensively used in Ayurveda, used in treatments related to neurological complications was used now in our study. Methods: In the present experiment, rats were divided into four groups of six in each group: group 1 received saline water, group 2 received rotenone (RT) through ...
متن کاملNa/K, Mg and Ca ATPase ACTIVITY IN DIFFERENT REGIONS OF RAT BRAIN DURING ROTENONE INDUCED PARKINSON'S DISEASE AND PROTECTIVE ROLE OF BACOPA MONNIERI
Bacopa monnieri (BM; Family: Scrophulariaceae), also referred as Brahmi or Jalbrahmi has been used for centuries in Ayurvedic system of medicine as a brain tonic, memory enhancer, revitaliser of sensory organs, anti-anxiety, cardio-tonic, diuretic, antidepressant and anticonvulsant agent, and the pharmacological actions are mainly attributed to the saponin compounds present in the alcoholic ext...
متن کاملProtective Effect of Trehalose Against H2O2-induced Cytotoxicity and Oxidative Stress in PC-12 Cell Line and the Role of Heat Shock Protein-27
Background: Oxidative stress has been shown to be an important factor, which plays a significant role in the pathogenesis of neurodegenerative disorders. Heat Shock Protein-27 (HSP-27) has been implicated in antioxidant responses against oxidative stress. Trehalose is a natural disaccharide widely used in a variety of food products with demonstrated protective effects against several neurodegen...
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ژورنال
عنوان ژورنال: International Journal of Phytomedicine
سال: 2017
ISSN: 0975-0185
DOI: 10.5138/09750185.2008