Protective effect of n-acetyl-L-cysteine and rosuvastatin against oxidative stress in fibroblasts from asymptomatic patients with X-ALD: a preliminary study

Introduction: Several studies in the literature have evaluated role of oxidative stress and adjuvant therapies for X-linked adrenoleukodystrophy (X-ALD). Here, we investigated whether n-acetyl-L-cysteine (NAC) rosuvastatin (RSV) could influence generation reactive species, redox status nitrative fibroblasts from asymptomatic patients with X-ALD. Methods: Skin biopsy samples were cultured treated 2 hours (37 °C) NAC RSV. Results: X-ALD generated high levels oxygen species. These significantly lower RSV relative to untreated samples. The also had higher catalase activity, only was able increase enzyme activity Conclusion: Our results indicated that improve parameters X-ALD, showing antioxidant therapy may be a promising treatment strategy this disease.