Protective effect of bovine lactoferrin against Cronobacter sakazakii in human intestinal Caco-2/TC7 cells
نویسندگان
چکیده
Milk is a source of bioactive proteins with defensive properties great value for protecting the newborn. The activity bovine milk lactoferrin (LF) was investigated as an antibacterial agent in internalisation emergent pathogen Cronobacter sakazakii into Caco-2/TC7 cells, model human intestinal epithelium. effect LF on oxidative stress and expression Toll-like receptors (TLR) also investigated. exerted clear against C. sakazakii, well inhibitory adhesion cells. Incubation induced increase lipid fraction which reversed by LF. Additionally, altered TLR, decrease levels TLR4 at 24 h incubation. These results suggest that has very interesting potential ingredient functional foods.
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ژورنال
عنوان ژورنال: International Dairy Journal
سال: 2022
ISSN: ['1879-0143', '0958-6946']
DOI: https://doi.org/10.1016/j.idairyj.2022.105428