Protection of the rat brain from hypothermic circulatory arrest injury by a chipmunk protein
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چکیده
منابع مشابه
Neurologic Injury Following Hypothermic Circulatory Arrest
Cardiothoracic surgeons are faced with the challenge of protecting the brain during the sensitive time of interruption of normal cerebral blood flow. The brain is an exceptionally complex organ with a functional anatomy that is difficult both to understand and assess. Experimental and clinical studies have shown that the mechanism of neural injury is multifactorial. As such, discussions regardi...
متن کاملDeep hypothermic circulatory arrest.
Effective cerebral protection remains the principle concern during aortic arch surgery. Hypothermic circulatory arrest (HCA) is entrenched as the primary neuroprotection mechanism since the 70s, as it slows injury-inducing pathways by limiting cerebral metabolism. However, increases in HCA duration has been associated with poorer neurological outcomes, necessitating the adjunctive use of antegr...
متن کاملDeep hypothermic circulatory arrest and the effects on the brain
The effect of deep hypothermic circulatory arrest (DHCA) in children with congenital heart disease on subsequent cognitive and motor performance is of great importance, and a number of case reports and patient series document neurological impairment associated with DHCA(1,2). However, only one large, controlled investigation of this issue has been conducted. Between 1988 and 1992, 171 infants w...
متن کاملProtecting The Brain During Deep Hypothermic Circulatory Arrest
Neurological complications after cardiac surgery are a recognized source of prolonged hospitalization, high hospital cost, altered quality of life, and mortality. Surgery involving the aortic arch is a particularly high risk procedure associated with stroke rates over four times higher than after CABG surgery (~9% vs ~2%). Although the use of selective antegrade cerebral perfusion via the brach...
متن کاملRemote ischemic preconditioning protects the brain against injury after hypothermic circulatory arrest.
BACKGROUND Ischemic preconditioning (IPC) is a mechanism protecting tissues from injury during ischemia and reperfusion. Remote IPC (RIPC) can be elicited by applying brief periods of ischemia to tissues with ischemic tolerance, thus protecting vital organs more susceptible to ischemic damage. Using a porcine model, we determined whether RIPC of the limb is protective against brain injury cause...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2018
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2018.02.048