Protecting the developing brain by 17β-estradiol
نویسندگان
چکیده
منابع مشابه
Protecting the developing brain by 17βestradiol
Among estrogen hormones, 17β-estradiol (17βE2) is the most potent natural form in circulation in mammals. It is known for its role in fetal development, fertility, sexual dimorphism, bone structure, and also for its role in breast or other hormone-dependent cancers. It has also remarkable effects on several systems including the cardiovascular, immune, and nervous systems [1]. 17βE2 is a lipoph...
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Estradiol is the most potent and ubiquitous member of a class of steroid hormones called estrogens. Fetuses and newborns are exposed to estradiol derived from their mother, their own gonads, and synthesized locally in their brains. Receptors for estradiol are nuclear transcription factors that regulate gene expression but also have actions at the membrane, including activation of signal transdu...
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In mammals, estrogens have both doseand cell-type specific effects on immune cells and may act as pro-inflammatory and anti-inflammatory stimuli depending on the setting. Evidence has been provided that in the bivalve mollusc Mytilus the natural estrogen 17β-estradiol (E2) can affect neuro-immune functions. In this work the immunomodulatory role of E2 in Mytilus hemocytes, the cells responsible...
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17β-Estradiol (E2) is a well-known neuroprotective factor in the brain. Recently, our lab demonstrated that the neuroprotective and cognitive effects of E2 require mediation by the estrogen receptor (ER) coregulator protein and proline-, glutamic acid-, and leucine-rich protein 1 (PELP1). In the current study, we examined whether E2, acting via PELP1, can exert anti-inflammatory effects in the ...
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D-Aspartic acid is an endogenous amino acid occurring in the endocrine glands as well as in the nervous system of various animal phyla. Our previous studies have provided evidence that D-aspartate plays a role in the induction of estradiol synthesis in gonads. Recently, we have also demonstrated that D-aspartic acid induces P450 aromatase mRNA expression in the frog (Pelophylax esculentus) test...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.14819