Protecting-group-free synthesis of the bisindolylmaleimide GF109203X
نویسندگان
چکیده
منابع مشابه
The catalytic enantioselective, protecting group-free total synthesis of (+)-dichroanone.
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متن کاملDirect block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X).
OBJECTIVE The human ether-a-go-go-related gene (hERG) encodes the rapid component of the cardiac repolarizing delayed rectifier potassium current, I(Kr). The direct interaction of the commonly used protein kinase C (PKC) inhibitor bisindolylmaleimide I (BIM I) with hERG, KvLQT1/minK, and I(Kr) currents was investigated in this study. METHODS hERG and KvLQT1/minK channels were heterologously e...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2015
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.p008.950