Proteasome inhibitor MG ‐132 induces MCPIP 1 expression
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چکیده
منابع مشابه
Proteasome inhibitor MG-132 induces MCPIP1 expression
The proteasome is a protein complex responsible for the degradation of polyubiquitin-tagged proteins. Besides the removal of target proteins, the proteasome also participates in the regulation of gene transcription in both proteolytic and non-proteolytic fashion. In this study the effect of proteasome inhibition on the basal expression of monocyte chemotactic protein-1 induced protein 1 (MCPIP1...
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Proteasome is a proteolytic complex responsible for intracellular protein turnover in eukaryotes, archaea and in some actinobacteria species. Previous work has demonstrated that in Schistosoma mansoni parasites, the proteasome inhibitor MG-132 affects parasite development. However, the molecular targets affected by MG-132 in S. mansoni are not entirely known. Here, we used expression microarray...
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The proteins' ubiquitination and their further degradation by proteasomes are crucial for cell cycle regulation, transcription and DNA replication, inflammatory response, and apoptosis. Proteasome inhibitors have recently become considered as a promising method in cancer and inflammatory disease therapy. In this study, utilizing the rat model, we try to establish the influence of proteasome inh...
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Dysfunctions of ubiquitin proteasome system (UPS), intracellular protein degradation mechanism lead to the aggregation of aberrant proteins, which is a hallmark of Parkinson’s disease (PD). Heat shock proteins (HSP) assist in refolding of misfolded proteins and in proper functioning of UPS. Thus, the neuroprotective potentials of carbenoxolone (Cbx), a HSP inducer were evaluated in a PD model g...
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The aim of the present study was to investigate whether endoplasmic reticulum (ER) stress is involved in MG‑132‑induced autophagy, and to determine the effects of the inhibition of autophagy and ER stress on cell viability following MG‑132 treatment. The proteasome inhibitor, MG‑132, was used to induce autophagy in MCF‑7 cells, and 3‑methyladenine (3‑MA) and salubrinal were used to inhibit auto...
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ژورنال
عنوان ژورنال: The FEBS Journal
سال: 2013
ISSN: 1742-464X,1742-4658
DOI: 10.1111/febs.12264