Proteasome inhibitor-based therapy for antibody-mediated rejection

Antibody-mediated rejection.

The introduction of both complement 4d (C4d) staining in renal allograft biopsies and sensitive methods to detect anti-human leukocyte antigen antibodies, such as single antigen bead flow assays, into tissue-typing techniques have shown the importance of antibody-mediated alloimmune response in kidney transplantation. The use of these sensitive methods, combined with the increased number of tra...

Antibody-Mediated Lung Transplant Rejection.

Antibody-mediated rejection after lung transplantation remains enigmatic. However, emerging evidence over the past several years suggests that humoral immunity plays an important role in allograft rejection. Indeed, the development of donor-specific antibodies after transplantation has been identified as an independent risk factor for acute cellular rejection and bronchiolitis obliterans syndro...

Advances in Antibody Mediated Rejection

Antibody mediated rejection: update 2006.

I t now is recognized that both acute and chronic allograft rejection may be mediated by alloantibodies. This constitutes a major shift in our thinking over the past 40 yr. We previously reviewed the articles that are relevant to the humoral theory: McKenna et al. (1), Terasaki (2), Cai and Terasaki (3), and Terasaki and Cai (4). Here we review articles that have appeared since our last review....

Antibody-Mediated Kidney Allograft Rejection

Successful kidney transplantation improves the quality of life and increases survival when compared with long-term dialysis. Renal transplantation is now a well established and the preferred treatment for most patients with end-stage renal disease (ESRD). In recent years, the short-term effects of kidney transplantation have been greatly achieved due to the improvement in immunosuppression medi...