منابع مشابه
Screening Efficacy of Available HIV Protease Inhibitors on COVID-19 Protease
Background and Aim: Advent of COVID-19 attracted the attentions of researchers to develop drugs for its treatment. Besides efforts on developing new drugs, screening available drugs for efficacy on COVID-19 could be an urgent action of initiating its pharmacotherapy. In this study, efficacy of HIV protease inhibitors on COVID-19 protease has been examined. Methods: Molecular docking based scree...
متن کاملClinical Pharmacology of Protease Inhibitors in HIV Infection
INTRODUCTION The past few years have reformed the manner in which management and monitoring of HIV patients has taken place. Improved therapeutic regimes and developments have allowed the movement away from monotherapy, to that of combination therapy. Protease Inhibitors are the recently developed drugs (1995) that are now used in triple drug therapy to lower viral load, increase CD4+ T counts,...
متن کاملInsulin Resistance in HIV Infection: Effects of Protease Inhibitors
Protease inhibitors (PIs) are widely assumed to induce a syndrome of insulin resistance accompanied by hyperlipidemia and fat redistribution that resembles the metabolic syndrome with its increased risk of cardiovascular disease. Researchers now believe, however, that numerous factors contribute to the metabolic alterations observed in HIV-infected patients and that some of these factors may be...
متن کاملHIV-1 protease inhibitors.
Treatment of human immunodeficiency virus type 1 (HIV-1) infection with regimens that include protease inhibitors (PIs) has contributed to marked improvements in HIV-related disease progression and mortality. Five PIs are approved by the US Food and Drug Administration and have potent activity in vitro. PIs with 2 nucleoside analogue reverse transcriptase inhibitors have demonstrated prolonged ...
متن کاملHIV protease inhibitors and atherosclerosis.
The advent of highly active antiretroviral therapy (HAART), including the use of HIV protease inhibitors (PIs) has significantly reduced the morbidity and mortality of AIDS in HIV infected patients. Unfortunately, the adverse effects of PIs, including dyslipidemia, lipodystrophy, insulin resistance, and premature atherosclerosis, are cause for concern for their use in chronic management of HIV ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1999
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.318.7176.122