Prostat Adenokarsinomunun tanı ve prognostik sınıflandırmasında CCR3 ekspresyonunun değeri

Objective: Chemokines are factors secreted from damaged or infected tissues to induce an inflammatory and immunological reaction. Approximately have recently been found be by most cancer cells. The aim of this study is compare the CCR-3 expression with clinicopathological variables in patients prostatic adenocarcinoma(PCa) benign hyperplasia(BPH). Material Method: included 25 PCa who underwent prostatectomy, BPH. In study, BPH was examined immunohistochemical method, at PCA compared normal prostate tissue mRNA level Real-Time PCR. Results: significantly higher (p=0,001). There no relationship between Gleason prognostic grade periprostatic spread (p=0,887, p=0,279). A statistically significant increase total PSA Conclusion: cancer, CCR3 receptor associated occurrence aggressive disease extended local dissemination a risk biochemical recurrence. According may useful predicting diagnosis there PSA. Increasing also correlation increased expression. However, grade.