Prostaglandin E2 receptors in bone formation
نویسندگان
چکیده
منابع مشابه
Prostaglandin E2 enhances alveolar bone formation in the rat mandible.
Prostaglandin E2 (PGE2) induces bone formation in stress-bearing bones. The mandible, a stress-bearing bone, is loaded daily during mastication. The aim of this study was to determine if PGE2 delivered locally to the mandible over 20 days enhances alveolar bone deposition. In 18 Lewis rats, controlled-release pellets containing PGE2 were implanted on the buccal aspect on the left-hand side of t...
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246 words Introduction: 534 words Discussion: 2209 words Abbreviations: COX, cyclooxygenase; COX-2, cyclooxygenase-2; TBS, tris-buffered saline; P-gp, P-glycoprotein; BBB, blood-brain barrier; PGE2, Prostaglandin E2; EEG, Electroencephalogram; NMDA, N-methyl-D-aspartic acid; CNS, central nervous system Section: Neuropharmacology This article has not been copyedited and formatted. The final vers...
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Chronic kidney disease is a leading cause of morbidity and mortality in the world. A better understanding of disease mechanisms has been gained in recent years, but the current management strategies are ineffective at preventing disease progression. A widespread focus of research is placed on elucidating the specific processes implicated to find more effective therapeutic options. PGE2, acting ...
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The anti-inflammatory drug licofelone [=ML3000; 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid], currently undergoing phase III trials for osteoarthritis, inhibits the prostaglandin (PG) and leukotriene biosynthetic pathway. Licofelone was reported to suppress the formation of PGE(2) in various cell-based test systems, but the underlying molecular mechan...
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OBJECTIVES To investigate the expression of prostaglandin E2 receptor subtypes, E-prostanoid (EP) 1-4 receptors, in acquired cholesteatoma and its possible role in the pathologic process of this disorder. METHODS Specimens of human acquired cholesteatoma were obtained from 29 patients and 19 skin biopsies of normal external auditory canal were as controls. The mRNA and protein expression of E...
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ژورنال
عنوان ژورنال: International Orthopaedics
سال: 2007
ISSN: 0341-2695,1432-5195
DOI: 10.1007/s00264-007-0406-x