Proresolving lipid mediators and liver disease

Inflammation is a characteristic feature of virtually all acute and chronic liver diseases. It intersects different pathologies from the early stages injury, when inflammatory burden mild-to-moderate, to very advanced disease, response intense drives multiple organ dysfunction failure(s). The current review describes most relevant features process in two clinical entities across disease spectrum, namely non-alcoholic steatohepatitis (NASH) acute-on-chronic failure (ACLF). Special emphasis given within these conditions gather data on specialized pro-resolving mediators that orchestrate resolution inflammation, tightly controlled which dysregulation commonly associates with conditions.