PROPORTIONALITY STUDIES ON CATALASE

Studies on the Effect of Temperature on the Catalase Reaction. Ii. Loss of Catalase Activity

In the preceding paper (1) the possibility of spontaneous inactivation of the enzyme by heat has been mentioned as a factor responsible for the diminished catalase activity, especially at temperatures above 20°C. To determine to what extent this may have played a r61e in the experiments at different temperatures, the activity of catalase subjected for various lengths of time to the influence of...

Studies on the Inactivation of Catalase Iii. Destruction of Catalase by Hydrogen Peroxide by Sergius Morgulis

Studies on catalase inhibition as related to tumors.

The inhibition of catalase in vitro by boiled extracts of tumors has been recently demonstrated (1). It was also found that fresh liver and spleen contained small amounts of a factor having similar action. In further work it was found that autolyzed liver homogenates contained large amounts of such inhibitory material. Studies on the rate of formation in liver homogenates, attempts at purificat...

Using SAS to Assess Dose Proportionality in Dose Escalation Studies

Dose escalation studies provide a good opportunity to assess the linearity of PK parameters. This paper describes hypothesis testing and confidence interval (C.I.) methods for assessing dose proportionality based on linear regression and weighted least squares (WLS) linear regression. SAS® code is presented using an example study and AUCinf data.

THE EFFECT OF GLUTARALDEHYDE ON CATALASE Biochemical and Cytochemical Studies with Beef Liver Catalase and Rat Liver Peroxisomes

Peroxidatic activity of catalase (E .C .1 .11 .1 .6) was discovered by Keilin and Hartree (1), and it has been firmly established that, catalase oxidizes various substrates such as ethanol, methanol, nitrite, and formate (2-4) . Crystalline beef liver catalase, used as an enzyme tracer (5), and the peroxisomal catalase (6, 7) have been visualized cytochemically by a modification of the 3,3'diam...