Proportional-Integral-Derivative (PID) Control of Secreted Factors for Blood Stem Cell Culture
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منابع مشابه
Proportional-Integral-Derivative (PID) Control of Secreted Factors for Blood Stem Cell Culture
Clinical use of umbilical cord blood has typically been limited by the need to expand hematopoietic stem and progenitor cells (HSPC) ex vivo. This expansion is challenging due to the accumulation of secreted signaling factors in the culture that have a negative regulatory effect on HSPC output. Strategies for global regulation of these factors through dilution have been developed, but do not ac...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0137392