Propofol induced unconsciousness: fMRI total neuronal activity and resting state networks
نویسندگان
چکیده
منابع مشابه
A transition in brain state during propofol-induced unconsciousness.
Rhythmic oscillations shape cortical dynamics during active behavior, sleep, and general anesthesia. Cross-frequency phase-amplitude coupling is a prominent feature of cortical oscillations, but its role in organizing conscious and unconscious brain states is poorly understood. Using high-density EEG and intracranial electrocorticography during gradual induction of propofol general anesthesia i...
متن کاملRapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness.
The neurophysiological mechanisms by which anesthetic drugs cause loss of consciousness are poorly understood. Anesthetic actions at the molecular, cellular, and systems levels have been studied in detail at steady states of deep general anesthesia. However, little is known about how anesthetics alter neural activity during the transition into unconsciousness. We recorded simultaneous multiscal...
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INTRODUCTION The mildly invasive 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a well-established imaging technique to measure 'resting state' cerebral metabolism. This technique made it possible to assess changes in metabolic activity in clinical applications, such as the study of severe brain injury and disorders of consciousness. OBJECTIVE We assessed the possibility of ...
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The Brain as a Dynamical Machine What the brain does is ultimately simple: it takes in sensory information, transforms it into an abstract code of spikes, and uses it to generate motor patterns. This spike code thus constitutes a mental representation of the world, which interacts with memories, expectations, motivations, and other internal states of the animal to generate a series of behaviors...
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Propofol is one of the most commonly used anesthetics in the world, but much remains unknown about the mechanisms by which it induces loss of consciousness. In this resting-state functional magnetic resonance imaging study, we examined qualitative and quantitative changes of resting-state networks (RSNs), total brain connectivity, and mean oscillation frequencies of the regional blood oxygenati...
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ژورنال
عنوان ژورنال: Frontiers in Human Neuroscience
سال: 2012
ISSN: 1662-5161
DOI: 10.3389/conf.fnhum.2012.210.00061