PROPHYLACTIC VACCINATIONS

Microenvironment and Immunology Booster Vaccinations against Cancer Are Critical in Prophylactic but Detrimental in Therapeutic Settings

Although cancer vaccines are in the clinic, several issues remain to be addressed to increase vaccine efficacy. In particular, whether how and how frequently a patient should be boosted remains to be defined. Here, we have assessed the ability of dendritic cell (DC)-based vaccines to induce a long-lasting tumorspecific CTL response in either prophylactic or therapeutic settings by taking advant...

Booster vaccinations against cancer are critical in prophylactic but detrimental in therapeutic settings.

Although cancer vaccines are in the clinic, several issues remain to be addressed to increase vaccine efficacy. In particular, whether how and how frequently a patient should be boosted remains to be defined. Here, we have assessed the ability of dendritic cell (DC)-based vaccines to induce a long-lasting tumor-specific CTL response in either prophylactic or therapeutic settings by taking advan...

Vaccinations of International Travelers

Meningococcal Vaccinations

Neisseria meningitidis, a gram-negative diplococcal bacterium, is a common asymptomatic nasopharyngeal colonizer that may infrequently lead to invasive disease in the form of meningitis or bacteremia. Six serogroups (A, B, C, W, X and Y) are responsible for the majority of invasive infections. Increased risk of disease occurs in specific population groups including infants, adolescents, those w...

Potential Benefits of Vaccinations

Introduction We live in an age of incredible technology, discovery and medicine. Smartphones, spaceships, and bionic eyes are no longer reserved for science fiction. Vaccinations are among the groundbreaking medical discoveries which “allow us to engage our adaptive immune systems to produce highly specific antibodies and immunological memory against a potential future infection” (Federman, 201...