Properties of Partially Purified Carnitine Acetyltransferase
نویسندگان
چکیده
منابع مشابه
Properties of partially purified carnitine acetyltransferase.
Subsequent reports from our laboratory showed that both carnitine (/3-hydroxy-y-trimethylammonium butyrate) and acetylcarnitinei increased oxygen uptake and oxidation of long chain fatty acids by heart homogenates incubated under conditions optimal for fatty acid oxidation (2, 3). Acetylcarnitine action could not be attributed simply to formation of carnitine via hydrolysis because acetylcarnit...
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Some of the kinetic properties of carnitine acetyltransferase in brain homogenates have been reported with the use of a new, sensitive radiometric method for the determination of acetylcarnitine. Those properties and the distribution pattern of carnitine acetyltransferase in various rat tissues, subcellular fractions, and discrete areas of the brain have been compared with those obtained for ch...
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Adenosine kinase has been partially purified from homogenates of rabbit liver and Ehrlich ascites tumor cells. The kinase preparation obtained was free of adenosine deamlnase and almost free of adenosine triphosphatase activity. In addition to adenosine, 34 analogues or derivatives of adenosine have been investigated with the enzyme. Of these compounds, 16 were substrates, and the Michaelis con...
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A kinase that catalyzes the phosphorylation of deoxycytidine has been purified 150-fold from L1210 murine leukemia cells. The reaction requires a divalent cation (preferably Mg++ or Mn++) and a nucleoside triphosphate. Optimal activity was obtained with ATP. Phosphorylation of deoxycytidine was competitively inhibited by both proximal (dCMP) and distal (dCDP and dCTP) end products and by cytosi...
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The activity of deoxythymidine kinase appears related to the proliferative ability of the cell (l-6). In adult rat liver, deoxythymidine kinase activity is virtually undetectable but appears rapidly during liver regeneration (I, 5, 7-10); the enhancement in the latter case is completely blocked by X-irradiation (II). Deoxythymidine kinase activity is also markedly enhanced in the livers of rats...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1963
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)68001-4