منابع مشابه
MicroRNAs silence gene expression by repressing protein expression and/or by promoting mRNA decay.
microRNAs (miRNAs) represent a novel class of genome-encoded eukaryotic regulatory RNAs that silence gene expression posttranscriptionally. Although the proteins mediating miRNA biogenesis and function have been identified, the precise mechanism by which miRNAs regulate the expression of target mRNAs remains unclear. We summarize recent work from our laboratory demonstrating that miRNAs silence...
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Amani was a 24-year-old woman in her second year of nursing school in Jerusalem. She lived with her extended family, including her parents, grandparents, and six older brothers, who had emigrated from Syria more than 10 years earlier. They are religious Muslim Arabs who lived in an Arab village not far from our cancer center in Jerusalem. For more than a year, Amani had experienced symptoms of ...
متن کاملBreaking the silence
" Like all good memoirs it has not been emasculated by considerations of good taste. " That was Peter Medawar's verdict on The Double Helix, Jim Watson's ebullient succès de scandale. Watson's exuberant style, let it be said right away, is not Maurice Wilkins's. He and Francis Crick were outraged by Watson's account — now a modern classic, at number seven in the American Modern Library's roll o...
متن کاملChromatin: A sticky silence
Recent findings indicate that heterochromatin serves as a molecular sink for factors involved in chromatin-mediated repression of gene expression; long-range interactions that position a euchromatic gene near a heterochromatin domain influence its susceptibility to transcriptional silencing.
متن کاملHeterochromatin: silence is golden
The large genomes of higher eukaryotes suggest a need for stable packaging, particularly as most of the DNA does not code for proteins, and much consists of repetitious sequences, including remnants of invading retrotransposons, transposable elements and the like. Cytological studies first demonstrated that much of the repetitous DNA is packaged in a condensed form referred to as heterochromati...
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ژورنال
عنوان ژورنال: Nature Reviews Microbiology
سال: 2006
ISSN: 1740-1526,1740-1534
DOI: 10.1038/nrmicro1336