منابع مشابه
Promoting human promoters
The effect of transcription factors on human gene expression can now be quantified owing to a new computational approach. The method was successfully applied to the cases of the cell cycle program, and for liver-specific gene expression. Transcriptional regulation of gene expression plays a major role in the acquisition of cell identity during embryogenesis and shapes cellular response to vario...
متن کاملNEWS AND VIEWS Promoting human promoters
The effect of transcription factors on human gene expression can now be quantified owing to a new computational approach. The method was successfully applied to the cases of the cell cycle program, and for liver-specific gene expression. Transcriptional regulation of gene expression plays a major role in the acquisition of cell identity during embryogenesis and shapes cellular response to vario...
متن کاملRegulation of the multiple promoters of the human aldolase A gene: response of its two ubiquitous promoters to agents promoting cell proliferation.
The human aldolase A gene is transcribed from three distinct promoters, the two ubiquitous promoters PN and PH and the muscle specific promoter PM. In the present study, we investigate further aldolase A mRNA structure and expression. We demonstrate that the upstream N-type exon is, in fact, extremely heterogeneous. RNAse H mapping experiments permit quantification of relative abundance of N, M...
متن کاملA discrimination study of human core-promoters.
A core-promoter, approximately from -60 bp upstream to +40 bp downstream of a RNA polymerase (RNAP) II transcription start site (TSS), binds to the preinitiation complex (PIC) and determine the position of TSS. Using position-specific k-tuple feature variables, a quadratic discriminant analysis (QDA) method is shown to be very effective in identifying human core-promoters.
متن کاملClustering of DNA sequences in human promoters.
We have determined the distribution of each of the 65,536 DNA sequences that are eight bases long (8-mer) in a set of 13,010 human genomic promoter sequences aligned relative to the putative transcription start site (TSS). A limited number of 8-mers have peaks in their distribution (cluster), and most cluster within 100 bp of the TSS. The 156 DNA sequences exhibiting the greatest statistically ...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2006
ISSN: 1744-4292,1744-4292
DOI: 10.1038/msb4100072