Promoter Activity of Sequences Located Upstream of the Human Papillomavirus Types 16 and 18 Late Regions

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Presence of Human Papillomavirus -16 and -18 Among Women with Breast Cancer in Isfahan Province

Background: Various studies proposed virus infection is to be a possible cause of human breast cancer. However, the data argue the association between virus and cancer are inconsistent. This study was conducted to detect whether HPV-DNA is present in tissue samples of breast cancer in Isfahan province. Materials and Methods: Paraffin embedded formalin fixed specimens were prepared from 40 brea...

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Human papillomavirus types 16 and 18 and the prognosis of patients with stage I cervical cancer

OBJECTIVE This study sought to evaluate the prevalence of human papillomavirus (HPV) types 16 and 18 in women with clinical stage IB cervical cancer treated by radical hysterectomy with pelvic lymphadenectomy as well as to establish a correlation between HPV type and cancer prognosis. METHODS A single-center cohort study was conducted with 86 patients who had undergone radical hysterectomy fo...

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Regulation of the human papillomavirus type 16 late promoter by E7 and the cell cycle.

Human papillomaviruses (HPVs) are the causative agents of cervical and other cancers. The oncoprotein E7 activates the cell cycle and makes possible replication of the viral genome in differentiating epithelia. The HPV16 late promoter is activated upon cellular differentiation and regulates late gene expression. We investigated the effect of E7 on the late promoter and found that E7 was able to...

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Viral DNA Replication Orientation and hnRNPs Regulate Transcription of the Human Papillomavirus 18 Late Promoter

The life cycle of human papillomaviruses (HPVs) is tightly linked to keratinocyte differentiation. Although expression of viral early genes is initiated immediately upon virus infection of undifferentiated basal cells, viral DNA amplification and late gene expression occur only in the mid to upper strata of the keratinocytes undergoing terminal differentiation. In this report, we show that the ...

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ژورنال

عنوان ژورنال: Journal of General Virology

سال: 1996

ISSN: 0022-1317,1465-2099

DOI: 10.1099/0022-1317-77-9-2193