Prolonged neuromuscular blockade by non-depolarizing neuromuscular blocking agents
نویسندگان
چکیده
منابع مشابه
Pharmacodynamics of non-depolarizing neuromuscular blocking agents.
When a clinical dose of a competitive neuromuscular blocking drug is given I.V. to a patient, a period of latency is followed by a progressive onset of blockade until a maximum is reached after several minutes. Thereafter, the intensity of block declines gradually. The precise relationship between the dose of drug and the time-course of the effect is complex, being dependent upon both pharmacok...
متن کاملInteractions between suxamethonium and non-depolarizing neuromuscular blocking drugs.
In anaesthetized cats, we have confirmed that previously injected suxamethonium potentiates non-depolarizing neuromuscular blocking drugs whereas, when injected during the block, suxamethonium antagonizes the paralysis. We have attempted to explain these interactions by studying the effects of suxamethonium on extracellularly recorded nerve ending waveforms that correspond to the ionic currents...
متن کاملNeuromuscular Blocking Agents
• Neuromuscular blocking agents are used to improve conditions for tracheal intubation, to provide immobility during surgery, and to facilitate mechanical ventilation. • The main site of action of neuromuscular blocking agents (muscle relaxants) is on the nicotinic cholinergic receptor at the endplate of muscle. They also have effects at presynaptic receptors located on the nerve terminal. • Su...
متن کاملComparative Effectiveness of Calabadion and Sugammadex to Reverse Non-depolarizing Neuromuscular-blocking Agents.
BACKGROUND The authors evaluated the comparative effectiveness of calabadion 2 to reverse non-depolarizing neuromuscular-blocking agents (NMBAs) by binding and inactivation. METHODS The dose-response relationship of drugs to reverse vecuronium-, rocuronium-, and cisatracurium-induced neuromuscular block (NMB) was evaluated in vitro (competition binding assays and urine analysis), ex vivo (n =...
متن کاملEffects of non-depolarizing neuromuscular blocking agents on the cardiac vagus nerve in the guineapig.
The ability of gallamine, metocurine, pancuronium, tubocurarine and atropine to block the response to postganglionic stimulation of the vagus nerve were measured in isolated, spontaneously beating guineapig atria. From analysis of the results in conjunction with those of earlier assays of concentrations that block effects of preganglionic vagal stimulation, it was concluded that only tubocurari...
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ژورنال
عنوان ژورنال: JA Clinical Reports
سال: 2019
ISSN: 2363-9024
DOI: 10.1186/s40981-019-0253-y