Proline isomerases function during heat shock.

Heat shock gene expression and function during zebrafish embryogenesis.

Recent work in the zebrafish, Danio rerio, indicates that heat shock genes are expressed in unique spatial patterns under non-stress conditions. In particular, hsp90alpha is expressed during the normal differentiation of striated muscle fibres, and hsp70-4 is expressed during normal lens development in the eye. Furthermore, disruption of the activity of either of these genes or their protein pr...

Prolyl Isomerases and Nuclear Function

(calcium-signal modulating cyclophilin ligand), and Cyp40 is part of the Hsp90/Hsc70 complex that binds steroid receptors. Likewise, FKBP12 is a subunit of two calcium Tony Hunter Molecular Biology and Virology Laboratory The Salk Institute channels (the ryanodine receptor and the IP 3 receptor), 10010 North Torrey Pines Road is needed for the function of the MDR drug efflux pump La Jolla, Cali...

Structure and Function: Heat Shock Proteins

Cytokine function of heat shock proteins.

Extensive work in the last 10 years has suggested that heat shock proteins (HSPs) may be potent activators of the innate immune system. It has been reported that Hsp60, Hsp70, Hsp90, and gp96 are capable of inducing the production of proinflammatory cytokines by the monocyte-macrophage system and the activation and maturation of dendritic cells (antigen-presenting cells) in a manner similar to ...

Interaction of the Neurospora crassa heat shock factor with the heat shock element during heat shock and different developmental stages.

The interaction of the heat shock factor (HSF) with the heat shock element (HSE) was determined by a non-radioactive electrophoretic mobility shift assay, in order to analyze HSF regulation in Neurospora crassa. HSF binds to HSE under normal, non-stress conditions and is thus constitutively trimerized. Upon heat shock, the HSF-HSE complex shows a retarded mobility. This was also observed in Sac...