Proliferation capacity of the renal proximal tubule involves the bulk of differentiated epithelial cells
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Proliferation capacity of the renal proximal tubule involves the bulk of differentiated epithelial cells.
We investigated the proliferative capacity of renal proximal tubular cells in healthy rats. Previously, we observed that tubular cells originate from differentiated cells. We now found 1) by application of bromo-deoxyuridine (BrdU) for 14 days and costaining for BrdU, and the G(1)-phase marker cyclin D1 that the bulk of cells in the S3 segment of juvenile rats were involved in proliferation; 2)...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2008
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00227.2007