منابع مشابه
Human prolactin: measurement in plasma by in vitro bioassay.
Prolactin has been measured in unextracted human plasma by a sensitive and specific in vitro bioassay. Secretory activity of breast tissue fragments from mid-pregnant mice, incubated in organ culture with human plasma, serves as the histologic end point. Sensitivity is 5 ng/ml (0.14 mU/ml) or somewhat better for ovine prolactin, and approximately 0.42 mU/ml for prolactin activity of human plasm...
متن کاملAnterior pituitary hormones: development of a bioassay leading to the discovery of prolactin.
TODAY, WE TAKE FOR GRANTED our knowledge about the six anterior pituitary hormones, their structure, function, and assays for measurement, and their central place in the regulation of critical body functions. However, younger generations of scientists may not understand the impact that their discovery and isolation had on the scientific community. In the 1920s, almost nothing was known about th...
متن کاملAntagonistic properties of human prolactin analogs that show paradoxical agonistic activity in the Nb2 bioassay.
Based on the assumption that the prolactin receptor (PRLR) is activated by PRL-induced sequential dimerization, potential human PRL (hPRL) antagonists were designed that sterically interfere with binding site 2. We previously reported the unexpected agonistic properties of these hPRL analogs in the rat Nb2 bioassay (Goffin, V., Struman, I., Mainfroid, V., Kinet, S., and Martial, J. A. (1994) J....
متن کاملThe bioassay for human prolactin and human chorionic somatomammotropin in serum from pregnant women and in amniotic fluid.
The bioactivity of human prolactin (hPRL) and human chorionic somatomammotropin (hCS) in the sera from the pregnant women (30-40weeks of gestation) and in the amniotic fluid (37-41weeks of gestation) were determined individually by the bioassay for lactogenic hormones using rat lymphoma cell bioassay in combination with the antibody blocking method. The bioactivity of hPRL in the pregnant sera ...
متن کاملNCBI PubChem BioAssay Database
NCBI’s PubChem BioAssay database (1-5) (http://pubchem.ncbi.nlm.nih.gov) is a public repository for archiving biological tests of small molecules and siRNA reagents. Small molecule bioactivity data contained in the BioAssay database consist of information generated through high-throughput screening experiments, medicinal chemistry studies, chemical biology research, as well as literature curati...
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ژورنال
عنوان ژورنال: Folia Endocrinologica Japonica
سال: 1971
ISSN: 0029-0661
DOI: 10.1507/endocrine1927.47.2_92