‘Project match hypotheses’: what this monograph aims to achieve

Patient management and clinical decision making in HBV--aims of therapy and what we can achieve.

International treatment guidelines for hepatitis B emphasize alanine aminotransferase (ALT) and serum HBV DNA thresholds, but strict adherence to these markers might lead to missed opportunities in some patients with acquisition in early life. Clinical trials have used improvement in liver histology, rate of hepatitis B e antigen seroconversion and sustained HBV DNA suppression as primary end p...

Deterministic Sample Consensus with Multiple Match Hypotheses

RANSAC (Random Sample Consensus) is a popular and effective technique for estimating model parameters in the presence of outliers. Efficient algorithms are necessary for both frame-rate vision tasks and offline tasks with difficult data. We present a deterministic scheme for selecting samples to generate hypotheses, applied to data from feature matching. This method combines matching scores, am...

HEAL Project Aims to Regenerate Human Limbs by 2030

How to avoid negative appendectomies: Can US achieve this?

BACKGROUND Clinical diagnosis of acute appendicitis is based primarily on symptoms and physical findings. However, diagnosis of appendicitis is not always straightforward. The aim of this study was to demonstrate the diagnostic effectiveness of ultrasonography (US) in these cases in combination with white blood cell count (WBC) and C-reactive protein (CRP) level. METHODS Retrospective analysi...

What does randomisation achieve?

What are the benefi ts of random allocation in clinical studies? John Worrall, a philosopher of science, recently questioned whether evidence-based medicine’s advice to base therapeutic decisions on the results of randomised controlled trials (RCTs) could be justifi ed.1 2 Here we provide a response to Worrall and others who challenge the epistemological value of RCTs. Worrall’s primary target ...