Proinflammatory role of monocytes in SARS-CoV-2 infection in chronic hemodialysis patients

Background Fully mature monocytes that express CD14, but not CD16, undergo phagocytosis within tissues, whereas non-classical monocytes, CD14-low CD16+, represent <11% of peripheral and have primary pro-inflammatory functions. Inflammation plays a major role in Covid-19 disease adds to the inflammation caused by chronic hemodialysis. The aim our study was monitor monocyte subsets five patients with end-stage kidney (ESKD) over 1-year period after mild infection. Five ESKD infection were monitored using CD300e, HLA-DR, CD64, CD45 panels BD FACS Canto flow cytometer. Results CD16+ dramatically (p=0,001) decreased during infection, as previously described for without renal failure. In addition, remained 10 months recovery from Covid. Intermediate increased this subtype retained their inflammatory activity significant increase HLA-DR expression Covid Conclusion Our shows had profile induced 19, status prolonged significantly 10-month period. Thus, advanced failure treated hemodialysis did change response against SARS 2. It seems retain many