Progressive diffuse pulmonary Langerhans cell histiocytosis improved by cladribine chemotherapy
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چکیده
منابع مشابه
chemotherapy cell histiocytosis improved by cladribine Progressive diffuse pulmonary Langerhans
UK and USA has serious side effects because of systemic dissemination of small particles. They omitted, however, an important experimental study which used larger talc particles (ie, the talc currently used in Europe for .70 years) and clearly showed that this talc does not disseminate in organs, unlike previous studies using American or Brazilian talc. This explains why many European respirato...
متن کاملCladribine activity in adult langerhans-cell histiocytosis.
Langerhans-cell histiocytosis (LCH) results from the accumulation of tissue histiocytes derived from the same progenitor cells as monocytes. Because cladribine is potently toxic to monocytes, we conducted a phase II trial of cladribine. Cladribine was administered to 13 LCH patients at 0.14 mg/kg per day by 2-hour intravenous infusion for 5 consecutive days, every 4 weeks for a maximum of six c...
متن کاملPulmonary langerhans cell histiocytosis
Pulmonary Langerhans' cell histiocytosis (PLCH) remains an important diagnostic consideration in the differential diagnosis of diffuse infiltrative lung disease, particular among smokers. This review highlights recent progress in our understanding of the etiology, clinical presentation, and diagnostic and therapeutic approaches to this unusual lung disorder. Evolving studies strongly link the b...
متن کاملPulmonary Langerhans cell Histiocytosis.
Pulmonary Langerhans cell Histiocytosis is a rare granulomatous disease affecting both sexes, with greater incidence in the second and third decades of life; smoking appears to be the most important risk factor. Its etiology is unknown, although there are data indicating an uncontrolled immune response as possible cause, sustained by the Langerhans cells, antigen presenting cells for T lymphocy...
متن کاملLangerhans cell histiocytosis
Introduction: Langerhans cell histiocytosis (LCH), which was previously known as histiocytosis X, refers to a group of lesions that stimulate uncontrolled proliferation of cells. The purpose of this case was to report and describe a LCH case with mandibular bone involvement in a 2.5-year-old boy. Case reports: A 2.5 years old boy with LCH of mandibular jaw who has been treated by surgical inter...
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ژورنال
عنوان ژورنال: Thorax
سال: 2009
ISSN: 0040-6376
DOI: 10.1136/thx.2008.108944