Progressive Activation of CD127+132− Recent Thymic Emigrants into Terminally Differentiated CD127−132+ T-Cells in HIV-1 Infection
نویسندگان
چکیده
منابع مشابه
Progressive Activation of CD127+132− Recent Thymic Emigrants into Terminally Differentiated CD127−132+ T-Cells in HIV-1 Infection
AIM HIV infection is associated with distortion of T-cell homeostasis and the IL-7/IL7R axis. Progressive infection results in loss of CD127+132- and gains in CD127-132+ CD4+ and CD8+ T-cells. We investigated the correlates of loss of CD127 from the T-cell surface to understand mechanisms underlying this homeostatic dysregulation. METHODS Peripheral and cord blood mononuclear cells (PBMCs; CB...
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Most Forkhead box P3(+) (Foxp3(+)) CD4 regulatory T cell (Treg) precursors are newly formed thymocytes that acquire Foxp3 expression on antigen encounter in the thymus. Differentiation of Treg, however, can also occur in the periphery. What limits this second layer of self- and nonself-reactive Treg production in physiological conditions remains to be understood. In this work, we tested the hyp...
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BACKGROUND Common variable immunodeficiency (CVID) comprises a heterogeneous group of disorders classified as predominantly antibody deficiencies. The aim of this study was to analyze levels of naïve CD4+ T cells and recent thymic emigrant (RTE) cells in CVID patients and healthy controls. METHODS Twenty patients with CVID and 20 age- and sex-matched healthy controls were studied. CD4+ T cell...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0031148