منابع مشابه
Slowing the progression of heart failure.
Publication of the results of the U.S. carvedilol programme 1 ' 1 has created an international dilemma affecting patients, physicians and drug regulatory agencies. The data presented in the New England Journal of Medicine of 23 May 1996 were from the overall study population of 1094 patients with symptoms of chronic heart failure, a left ventricular ejection fraction <O35, and the ability to pe...
متن کاملEpidemiology of heart failure: progression to pandemic?
Congestive heart failure (CHF), traditionally considered an edematous disorder, was described hundreds of years ago. Hypertension and valvular heart disease were the most frequent co-morbidities [1]. Physicians could only attempt to control pulmonary and peripheral congestion with diuretic therapy. Heart failure was a progressive disease culminating in biventricular dysfunction, anasarca, and f...
متن کاملRoles of neurohumoral factors in the progression of heart failure.
has led to an appreciation of the clinical importance of achieving regression of cardiac hypertrophy, as well as control of blood pressure, in patients receiving antihypertensive therapy. The superiority of converting enzymeinhibitors compared to other antihypertensive agents in effecting regression of cardiac hypertrophy could be attributable to their characteristic profile of actions. By inhi...
متن کاملInfluence of angiotensin on the early progression of heart failure.
The purpose of this study was to elucidate the role of circulating ANG II in mediating changes in systemic and renal hemodynamics, salt and water balance, and neurohormonal activation during the early progression of heart failure. This objective was achieved by subjecting six dogs to 14 days of rapid ventricular pacing (240 beats/min) while fixing plasma ANG II concentration (by infusion of cap...
متن کاملRole of RyR2 phosphorylation at S2814 during heart failure progression.
RATIONALE Increased activity of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is thought to promote heart failure (HF) progression. However, the importance of CaMKII phosphorylation of ryanodine receptors (RyR2) in HF development and associated diastolic sarcoplasmic reticulum Ca(2+) leak is unclear. OBJECTIVE Determine the role of CaMKII phosphorylation of RyR2 in patients and mice ...
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ژورنال
عنوان ژورنال: Circulation
سال: 2002
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circ.105.3.272