Progress of sperm IZUMO1 relocation during spontaneous acrosome reaction
نویسندگان
چکیده
منابع مشابه
Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm.
Human membrane cofactor protein (MCP, CD46) is a ubiquitously expressed protein known to protect cells from complement attack. Interestingly, when we examined the expression of mouse CD46, which we recently cloned, the message was found only in testis and the protein was found on the inner acrosomal membrane of sperm. In order to elucidate the function of CD46, we produced mice carrying a null ...
متن کاملValue Analysis of Sperm Spontaneous Acrosome Reaction in Male Fertility Evaluation
Objective: Using correlation analysis between the sperm spontaneous acrosome reaction rate (SARR) and routine semen parameters in male infertility patients, we explored the value of the sperm spontaneous acrosome reaction in the evaluation of sperm functions. Methods: The participants comprised of 219 male infertility patients who had visited the Center for Reproductive Medicine, Shandong Unive...
متن کاملCytochrome c upregulation during capacitation and spontaneous acrosome reaction determines the fate of pig sperm cells: linking proteome analysis.
To identify the mechanisms underlying capacitation, we undertook a high-resolution differential proteomic analysis of pig sperm cells. Two-dimensional gel electrophoresis and subsequent MALDI-TOF mass spectrometry analyses led to identification of 56 differentially expressed proteins. After induction of capacitation in vitro, the well-established markers of the capacitation (lactadherin P47, ac...
متن کاملRole of tyrosine phosphorylation in sperm capacitation / acrosome reaction
Capacitation is an important physiological pre-requisite before the sperm cell can acrosome react and fertilize the oocyte. Recent reports from several laboratories have amply documented that the protein phosphorylation especially at tyrosine residues is one of the most important events that occur during capacitation. In this article, we have reviewed the data from our and other laboratories, a...
متن کاملSite of the mammalian sperm physiological acrosome reaction.
I n mammals and the many other animals in which fertilization involves the establishment of a penetration path through the egg coat, at the apex of the sperm head lies the acrosome— a membrane-limited organelle that houses a complex of enzymes. For fertilization to occur, spermatozoa must first undergo the acrosome reaction (AR), which involves point fusions between the outer acrosomal and over...
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ژورنال
عنوان ژورنال: REPRODUCTION
سال: 2014
ISSN: 1470-1626,1741-7899
DOI: 10.1530/rep-13-0193